La Roche Posay Adapalene Vs Differin 2022 Which One Is Better

La Roche Posay Adapalene Vs Differin 2022: Which One Is Better?

  • Post last modified:April 9, 2022
  • Reading time:9 mins read
  • Restorbio

Differin and La Roche-Posay Adapalene gel are both topical retinoids used to treat acne. They are both available as creams or gels applied to the skin. Both medications effectively treat acne, but they may have different side effects. The purpose of this article is to compare the two topical acne medications, La Roche Posay Adapalene Vs Differin, and help you know which should you choose.

La Roche Posay

La Roche-Posay is the most widely recommended dermo-cosmetic brand worldwide, with over 90,000. Dermatologists recommend it. They work with professionals and dermatologists to create innovative skincare solutions for sensitive skin.

Differin vs. La Roche-Posay Serum La Roche Posay

La Roche-Posay offers expert skincare recommendations from dermatologists, regardless all of the skin types. La Roche-Posay has solutions for sensitive, redness-prone, and aged skin.

It also provides high-quality suncare products and skincare products for children and babies. La Roche Posay offers a single-stop solution for all skin problems, from babies to adults.


Differin is the OTC retinoid that has Rx-strength anti-cancer properties. Retinoids play an essential role in the treatment of acne.

La Roche Posay Adapalene vs. Differin Differin

They regulate skin cell turnover, reduce inflammation deep under the skin, and help to prevent and clear pimples. Adapalene, a type of medicine, is a prescription-strength retinoid. It inhibits cell growth and reduces edema.

Differin’s Adapalene retinoid is gentler and more effective than other retinoids. This means that you don’t need to spend your entire life in the sun to have the clearer skin you desire.

This medication can be used to treat acne. This medication can be used to reduce the severity and number of acne pimples and accelerate the healing of existing ones.

Galderma Differin Gel 0.1% Adapalene

Galderma Differin Gel 0.1% Adapalene

Galderma’s Differin Acne Treatment Gel is the first and only FDA-approved full prescription-strength retinoid.

The acne treatments are available without a prescription in the US and are a dermatologist-developed and tested.

The active ingredient, Adapalene, is contained in the gel. It aims to reduce and eliminate both inflammatories and non-inflammatory acne treatments such as blackheads, cysts, whiteheads, and whiteheads.

It can target signs of aging, and improve minor concerns like hyperpigmentation and fine lines.


Differin Gel is a very straight-to-the-point product. Besides the active ingredient, it only contains a few more carbomers to provide thickness and viscosity to the formula and solvents to keep it stable for a long time.


Galderma’s Differin Gel is free of any fragrances or other fragrant ingredients. It also has no scent.


Adapalene is only available in Europe via prescription. However, I purchased Differin from a pharmacy that did not ask for a cure and charged me slightly more than regular.

You should apply Differin on dry, clean skin.

When I first began using it, I used Differin over my La Roche Posay Cicaplast Baume three times per week.

It quickly became a part of my skin, and I started using it three times per week. After two weeks, I was using it every night.

I experienced no irritation or peeling during this period. However, this was not my first experience using retinoids. I also stopped using any other activities for at most three weeks.

After three weeks of Differin daily use, I gradually transitioned into other actives like salicylic acid or niacinamide. This was also when I experienced a minor purge.

My forehead and temples felt a bit bumpy, and I also noticed a few pustular zits on my cheeks, nose, and chin. It is a common symptom when I try a new activity that causes purging.

It wasn’t serious, but I had a good routine before Differin, so it wasn’t surprising that I didn’t expect anything significant.

It was probably a combination of not exfoliating for three weeks and introducing a different activity at the time. The purge started three weeks after it began.

Although this is not a general rule, a retinoid purge may take up to three weeks to begin.

Apart from that, Differin’s texture was appealing to me initially. However, my perception changed eight weeks later when I tried La Roche Posay.

La Roche Posay Effaclar Adapalene Gel 0.1%

La Roche Posay Effaclar Adapalene Gel 0.1%

Effaclar Adapalene Gel 0.1% Acne Treatment was the second of the two products, and it was only launched a few years ago.

It is part of the brand’s Effaclar range, designed with oily and acne-prone complexions in mind.


The Adapalene Gel treatment is a very straight-to-the-point product. Besides the active ingredient, it only contains a few more carbomers to provide thickness and viscosity to the formula and solvents to keep it stable for a long time.


Adapalene Gel does not contain any additional fragrances or fragrant components. It also has no smell.


As I mentioned, Adapalene is only available in Europe via prescription. However, you can purchase them online without a prescription. I bought Galderma’s Differin from this website to see if it works.

I was still prescribed Adapalene Gel by La Roche Posay and asked for a refill. I wanted to review it.

Effaclar Adapalene Gel 0.1% Acne Treatment was my first choice. It lasted me eight weeks, with almost daily use.

It did not cause any irritation, redness, or sensitivity when I used it over my La Roche Posay Cicaplast Baume for the first few weeks.

I didn’t feel any new purging after switching from Differin to Effaclar Adapalene Gel 0.1% Acne Treatment. My skin kept improving.

I finally decided to use it after my moisturizer around the fourth week. I also used Differin for the eight previous weeks. My skin had become accustomed to the active ingredient, and there was no irritation.

I stopped moisturizing the product because it is gentler. I find it moisturizing enough by itself.

After Paula’s Choice 10% Niacinamide Booster, it’s my current nighttime use. I also use it in the morning when I’m not out of the house with sunscreen or makeup.

Effaclar Adapalene Gel 0.1% Acne Treatment is my preferred choice for Differin. It has a smoother texture and spreads quickly on the skin.

Differin has a stiffer consistency and doesn’t spread nearly as well as La Roche Posay due to the different carbomer.

Effaclar Adapalene Gel 0.1% Acne Treatment gives me a more flawless glow, and my skin feels softer than Galderma’s Diffin.

However, this could be because I’m experiencing the full effects of Adapalene after I’ve been using it for more than three months. That’s how long it takes for adapalene results to show.

Both products are approximately the same size and cost about the same with a $2 difference. I am deciding to stick with Effaclar Adapalene Gel 0.1% Acne Treatment as I like the texture and beautiful glow.

What’s the Distinction Between Differin Vs La Roche Posay Adapalene

What’s the Distinction Between Differin Vs La Roche Posay Adapalene?

Galderma’s Differin is different from Effaclar Adapalene Gel 0.1% Acne Treatment in that it contains an entirely different carbomer.

Differin lists Carbomer 940 as an ingredient, while La Roche Posay lists Carbomer Homopolymer.

The carbomer makes La Roche Posay’s product more spreadable and smoother than Differin. However, aside from how they feel on the skin and how it spreads, La Roche Posay’s product is essentially the same product.

Carbomers, a family of crosslinked acrylic acids polymers, are essential elements in many merchandises. They include prescription drugs and cosmetics; family, industrial and institutional care merchandise; printing Inks; adhesives and coatings.

Carbomers are used to create the desired aesthetics in merchandise. They can add viscosity or texture while stabilizing and prolonging their life.

Carbomers are non-hazardous and cause little or no irritation to the skin and eyes from the concentrations found in cosmetics and personal products.

Carbomers are often referred to as by-product builders as “a formulator’s best friend” because of their reliability, utility, and sometimes the ability to save doomed product launches by stabilizing poorly-conceived formulations towards separation.

La Roche Posay Adapalene Vs Differin: FAQs

La Roche Posay Adapalene Vs. Differin FAQs

Is La Roche Posay Cruelty Free?

La Roche-Posay does not practice cruelty. La Roche-Posay pays for and allows products to be tested on animals if required by law. La Roche-Posay sells its products in China, where animal testing for cosmetics is required.

Are La Roche-Posay Products Natural?

Ans. Ans. It was discovered in France hundreds of years ago in La Roche-Posay. Established researchers have recognized its skin-beneficial properties due to its high content in Selenium, a rare and remarkable regular cell reinforcement.

Which La Roche-Posay Moisturizer Is the Best?

Ans. Ans. The Hydraphase Intense Riche Hyaluronic acid, the Toleriane Dual Repair Face Moisturizer, and the Effaclar Mattifying Moisturizer For Oily Skin are the most effective La Roche-Posay creams.

Do you wash Differin Gel in the Morning?

Ans. Avoid skin products that dry skin or shed your skin. Adapalene can make your skin more sensitive to sunlight. It is best to apply Adapalene in the evening and then wash it off the following day.


After careful consideration, it is evident that La Roche-Posay Adapalene Gel 0.1% is a little more effective treatment for acne than Differin Gel 0.1%. Adapalene has been proven to be more effective in reducing the number of acne lesions and treating acne scars. We hope this article will help you choose a proper treatment and make you happier.

Chen Schor

Co-Founder, President and CEO of resTORbio Inc

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