Our Pipeline

We are a clinical-stage biopharmaceutical company developing innovative medicines that target the biology of aging to prevent or treat aging-related diseases.

Our lead program selectively inhibits the activity of a protein complex called target of rapamycin complex 1, or TORC1, an evolutionarily conserved pathway that contributes to the decline in function of multiple aging organ systems. Our lead product candidate is a TORC1 inhibitor called RTB101.

We are developing RTB101 alone and in combination with other TORC1 inhibitors for multiple aging-related diseases. In addition to developing our TORC1 product candidates, we are building a pipeline of products targeting multiple mechanisms underlying the biology of aging.

* For Parkinson’s disease, we may be required to file an investigational new drug application, or IND, prior to initiating Phase 2 clinical trials
** For neurodegenerative diseases and diseases associated with TORC1 hyperactivation, subject to review by the U.S. Food and Drug Administration, we believe we may have the ability to initiate Phase 2 clinical trials without the need to conduct additional Phase 1 trials.
Read on

About RTB101

Our lead product candidate, RTB101, is an investigational, oral, selective, and potent TORC1 inhibitor.

RTB101 inhibits the phosphorylation of multiple targets downstream of TORC1. Inhibition of TORC1 has been observed to extend lifespan and healthspan in aging preclinical species and to improve the function of multiple organ systems, including neurologic function, suggesting potential benefits in several aging-related diseases.

We currently have a Phase 1b/2a program for RTB101 alone and in combination with sirolimus in Parkinson’s disease. We expect to develop RTB101 for additional indications in other aging-related diseases.

About Parkinson’s Disease

Parkinson’s disease, or PD, is a progressive neurodegenerative disease that affects approximately 7.5 million people worldwide.

The incidence of PD increases rapidly in people 60 years of age and older, with a mean age at diagnosis of 70.5 years. In PD, neurodegeneration is thought to be caused, at least in part, by the accumulation of aggregates of a protein called alpha-synuclein that are toxic to neurons in the brain. Patients with PD develop shaking, rigidity, slowness of movement and difficulty walking.

Selective and broad inhibition of TORC1 has been shown to ameliorate neurodegenerative disease in several preclinical studies, including models of PD. TORC1 inhibition with RTB101 in combination with sirolimus, another TORC1 inhibitor, may provide a therapeutic benefit to PD patients by potentially inducing autophagy to clear the toxic alpha-synuclein aggregates in neurons.

We initiated our Phase 1a/2b clinical trial for PD in the first quarter of 2019. The trial is evaluating the safety, tolerability and brain penetration of RTB101 alone or in combination with sirolimus in PD patients.
Data from this trial is expected in mid-2020.
Read on

We are transiting into a blog that focus on beauty product review.

  1. Estee lauder advanced night repair ingredients
  2. Hanasui vitamin c serum ingredients
  3. Bio oil ingredients
  4. Eucerin aquaphor healing ointment ingredients
  5. Acnes vitamin c serum ingredients
  6. Bepantol Baby ingredients
  7. Natur e anti aging eye cream ingredients
  8. il makiage woke up like this ingredients
  9. Sheer joy sunscreen ingredients
  10. Olaplex no 4 shampoo ingredients
  11. Avoskin-miraculous-refining-toner ingredients
  12. TRESemmé hairspray ingredients
  13. e-l-f-poreless-putty-primer  ingredients
  14. Ivory original scent bar soap ingredients
  15. Cetaphil gentle-skin cleanser ingredients
  16. Olay regenerist micro-sculpting cream ingredients
  17. Janssen retin a tretinoina crema ingredients
  18. Bayer bepantol derma ingredients
  19. Aveeno daily moisturizing lotion ingredients
  20. Vaseline protecting jelly ingredients
  21. Okeeffes working hands hand-cream ingredients
  22. Kiehls ultra facial cream ingredients
  23. Aloe pura hudgel aloe-vera ingredients
  24. Ponds dry-skin cream ingredients
  25. Eucerin original healing cream ingredients
  26. Cerave moisturizing cream ingredients
  27. Cetaphil moisturizing lotion ingredients
  28. Avon skin so soft original bath oil spray ingredients
  29. Mederma advanced scar gel ingredients
  30. Ponds dry-skin cream ingredients